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. 2009 Dec;1(6):a003129. doi: 10.1101/cshperspect.a003129

Figure 1.

Figure 1.

Schematic overview of representative human members of the cadherin superfamily with reported involvement in cancer (modified after Hulpiau and van Roy 2009). All proteins are drawn to scale and aligned at their transmembrane domain (TM). Their total sizes are indicated on the right (number of amino acid residues). The following protein domains are shown: CBD, (conserved cadherin-specific) catenin binding domain; CD, unique cytoplasmic domain; CE, Cysteine-rich EGF repeat-like domain; CM1 to CM3, conserved motifs in the CDs of δ-protocadherins; EC, extracellular cadherin repeat; GPI, glycosylphosphatidylinositol anchor; JMD, (conserved cadherin-specific) juxtamembrane domain; LAG, laminin A globular domain; Pro-d, prodomain; TK, tyrosine kinase domain. On the basis of a phylogenetic analysis (Hulpiau and van Roy 2009), it was proposed that protocadherin LKC (PC-LKC or protocadherin-24) should be renamed (CDHR24).