Table 2.

Predictive accuracy (area-under-the-curve) of the kallikrein models in recently screened men, with 95% C.I. The base model for the laboratory model includes age and total PSA, and for the clinical model includes age, total PSA, and DRE result. The full model includes the base model plus free PSA, intact PSA, and hK2.

Model	Laboratory Model		Clinical Model
	Any cancer	High-grade cancer	Any cancer	High-grade cancer
Models developed with never screened men and applied to recently screened men
Base	0.514 (0.487, 0.546)	0.581 (0.493, 0.671)	0.569 (0.530, 0.608)	0.675 (0.585, 0.762)
Full	0.656 (0.621, 0.693)	0.781 (0.714, 0.844)	0.678 (0.643, 0.714)	0.800 (0.732, 0.859)
P value versus base	<0.001	<0.001	<0.001	0.004
Models developed with recently screened men and applied to recently screened men
Base model	0.564 (0.521, 0.603)	0.658 (0.557, 0.747)	0.622 (0.580, 0.661)	0.717 (0.625, 0.800)
Full model	0.674 (0.636, 0.711)	0.819 (0.751, 0.879)	0.697 (0.661, 0.734)	0.828 (0.769, 0.878)
P value versus base	<0.001	<0.001	0.005	0.009