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. Author manuscript; available in PMC: 2010 Jun 8.

Published in final edited form as: Neuroscience. 2006 May 2;140(2):607–622. doi: 10.1016/j.neuroscience.2006.02.055

Fig. 3 — Induction of cell death by METH as a function of dose. Mice were injected once with METH (i.p.) at the doses indicated. The mice were killed 24 h after METH and sections of striatal tissue were processed for TUNEL immunohistofluorescence. (A) Scanning confocal micrographs of TUNEL staining in the striatum of mice treated with increasing doses of METH (a–e). Scale bar=50 μm. (B) Percentage of striatal neurons displaying TUNEL staining for DM, VM, DL, and VL regions of the striatum (mean S.E.M.). * P<0.005, ** P<0.01, *** P<0.05 compared with saline control. (C) Scatter graphs indicate percentage of TUNEL-positive neurons for each animal within each treatment group. Each dot represents one animal. Blue=saline, red=METH 10 mg/kg, green=METH 20 mg/kg, purple=METH 30 mg/kg, yellow=METH 40 mg/kg; n=10–11 per experimental group.

Fig. 3 — Induction of cell death by METH as a function of dose. Mice were injected once with METH (i.p.) at the doses indicated. The mice were killed 24 h after METH and sections of striatal tissue were processed for TUNEL immunohistofluorescence. (A) Scanning confocal micrographs of TUNEL staining in the striatum of mice treated with increasing doses of METH (a–e). Scale bar=50 μm. (B) Percentage of striatal neurons displaying TUNEL staining for DM, VM, DL, and VL regions of the striatum (mean S.E.M.). * P<0.005, ** P<0.01, *** P<0.05 compared with saline control. (C) Scatter graphs indicate percentage of TUNEL-positive neurons for each animal within each treatment group. Each dot represents one animal. Blue=saline, red=METH 10 mg/kg, green=METH 20 mg/kg, purple=METH 30 mg/kg, yellow=METH 40 mg/kg; n=10–11 per experimental group.