Table 2.
| |||||
---|---|---|---|---|---|
product | R1 | R2 | R3 | dr | yield (%)a |
2g | H | H | Br | 22:1 | 78 |
2h | CF3 | H | H | >20:1 | 72 (87)b |
2i | H | H | CO2Me | >20:1 | 74 |
2j | H | H | H | 17:1 | 85 |
2k | OMe | H | H | >20:1 | 90 |
2l | Br | H | H | >20:1 | 67 |
2m | H | OMe | H | >20:1 | 95 |
2n | H | H | OMe | 17:1 | 63 |
2o | OMe | H | OMe | >20:1 | 78 |
2p | H | H | Me | >20:1 | 74 (85)b |
2q | H | F | F | 20:1 | 95c |
2r | NO2 | H | NO2 | 10:1 | 77c |
isolated yields, 0.25 mmol substrate
10 mol% TiCl4
performed on 3 mmol scale