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. Author manuscript; available in PMC: 2010 Jun 8.
Published in final edited form as: J Org Chem. 2009 Jun 19;74(12):4612–4614. doi: 10.1021/jo900367g

Table 2.

Scope of benzylidene malonates

graphic file with name nihms-204012-t0015.jpg
product R1 R2 R3 dr yield (%)a
2g H H Br 22:1 78
2h CF3 H H >20:1 72 (87)b
2i H H CO2Me >20:1 74
2j H H H 17:1 85
2k OMe H H >20:1 90
2l Br H H >20:1 67
2m H OMe H >20:1 95
2n H H OMe 17:1 63
2o OMe H OMe >20:1 78
2p H H Me >20:1 74 (85)b
2q H F F 20:1 95c
2r NO2 H NO2 10:1 77c
a

isolated yields, 0.25 mmol substrate

b

10 mol% TiCl4

c

performed on 3 mmol scale