Figure 2 Radial diffusivity over time in relation to gadolinium (Gd) enhancement, categorized by black hole outcome

During maximum Gd enhancement (time 0), radial diffusivity becomes elevated over baseline (time −1), regardless of lesion outcome. However, for lesions destined to become persistent black holes, radial diffusivity is larger than for lesions that do not become black holes. In addition, it remains elevated throughout the duration of follow-up.