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Steric relationship of some of the NBP residues surrounding an incoming dTTP paired opposite a templating A (from Franklin et al., PDB code 1IG9 (20)). A. The nascent base-pair and surrounding residues are shown from the duplex side of the primer-template in space-filling form (the terminal base-pair is shown in stick form (purple) for clarity). L561 and Y567 are shown in orange. B. Orthogonal view of (A), showing the close proximity of L561 with the templating base.
