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. Author manuscript; available in PMC: 2010 Jun 8.
Published in final edited form as: Biochemistry. 2010 May 18;49(19):4116–4125. doi: 10.1021/bi100102s

Figure 9.

Figure 9

Comparison of the Y567A mutant anti-8-oxoG:dCTP and syn-8-oxoG:dATP ternary crystal structures. A. Superimposed palm domains showing that 8-oxoG flips from anti to a syn conformation resulting in a shift of A567 and G568 into the minor groove of the primer-template by ~ 0.6 Å. The Y567A:anti-8-oxoG:dCTP backbone is shown in orange, and the Y567A:syn-8-oxoG:dATP backbone in yellow. B. Schematic illustration of the spatial interaction between G568 and the nascent base-pair as shown in (A).