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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Nano Today. 2010 Apr 1;5(2):143–159. doi: 10.1016/j.nantod.2010.03.003

Figure 3.

Figure 3

Transport of small and large molecular weight drugs and nanoparticles from defective tumor vasculature into tumor space. (a) Small molecular weight drugs (black) can diffuse out of tumor vasculature but can also diffuse back into tumor vasculature which allows clearance of these compounds from the tumor space. (b) Larger molecular weight drugs or nanoparticles (green) can diffuse into the tumor space but are retained due to the EPR effect. Reprinted from [10], Copyright 2006, with permission from Elsevier.