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. 2010 Jun 8;5(6):e10977. doi: 10.1371/journal.pone.0010977

Figure 4. Pdro knockdown increases plasma membrane projections and cholesterol esterification.

Figure 4

(A) Images of Filipin staining of SHEP cells treated for 72h with siPdro or scramble siRNA. Cholesterol-rich plasma membrane ruffles are indicated by arrows and filipodia by arrowheads. (B) Rate of cholesterol esterification in SHEP cells pre-treated for 72h with the indicated siRNA, followed by loading or not with 100 µg/ml AcLDL for 8h in the presence of [3H]oleate in lipoprotein-deficient serum. One representative experiment in triplicate wells is shown (*, p≤0.05 using Mann Whitney test).