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. 2010 Jun 8;5(6):e11001. doi: 10.1371/journal.pone.0011001

Figure 4. Critical period for ME-induced rearrangement of retinogeniculate projections.

Figure 4

ME was performed at the indicated time points, and CTB was injected into the other eye. Coronal sections through the dLGN ipsilateral to the CTB-injected eye were prepared 25–27 days later. The sizes of the CTB-positive areas relative to those of the dLGNs are shown. Note that the CTB-positive areas were significantly larger in mice treated with ME at P10 or at P22 compared with those in control mice. (**) P<0.01, (*) P<0.05, unpaired Student's t-test. The CTB-positive areas did not show significant differences when ME was performed at P34 (P = 0.91, unpaired Welch's t-test). These results suggest that the critical period for ME-induced rearrangement ends between P22 and P34. Error bars represent S.D. The numbers in parentheses indicate the number of animals.