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. 2010 Jun 8;5(6):e11013. doi: 10.1371/journal.pone.0011013

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Serial rapamycin whole blood concentrations (ng/ml) were measured by HPLC with MS/MS detection for all dogs that completed study (n = 19). After a single parenteral dose of rapamycin, 7-point PK analysis (samples collected at 0, 30 minutes, 1,2, 6, 24 and 48 hours) was performed. Over the dose range studied, A. average concentration – time curves for each dose level, and B. rapamycin exposure (AUC_0–48h) increased proportionally to dose.