Table 4. Median (Range) Non-Compartmental Pharmacokinetic Parameters in dogs with cancer after 8 days of exposure to rapamycin.

Dose Level	N	AUC0–48	Cmax	Tmax	C48h	CD8	CD9	CD15	T1/2
mg/kg		ng•hr/mL	ng/mL	h	ng/mL	ng/mL	ng/mL	ng/mL	h
0.01	3	47.4 (31.9–60.2)	1.27 (0.79–2.92)	24 (24–48)	0.91 (0.56–2.92)	2.78 (1.77–3.39)	1.92 (0.5–3.14)	0.45 (0–0.89)	114.6
0.02	4	64.3 (44.9–67.3)	1.69 (1.21–1.82)	24	1.26 (1.11–1.55)	5.63 (5.4–5.65)	5.93 (4.42–7.15)	0.86 (0.78–0.95)	70.8 (23.2–88)
0.04	3	105.4 (96.9–308.9)	2.87 (2.39–18.2)	24 (2–24)	1.86 (1.38–2.19)	6.62 (3.18–9.72)	7.92 (3.2–10.1)	1.56 (0.32–1.91)	62.7 (17.6–88.6)
0.06	7	285.2 (158.2–381.8)	7.29 (3.87–17.8)	6 (2–24)	3.61 (2.11–4.73)	9.84 (6.49–17.6)	9.3 (7.9–16.6)	1.04 (0.87–3)	72.7 (58.2–95.8)
0.08	4	309.3 (188.9–533.0)	12.14 (5.36–21.1)	15 (2–24)	4.6 (3.94–5.45)	15.4 (15.1–19.6)	16.4 (8.65–21.4)	3.66 (2.51–4.81)	86.6 (76.7–96.5)