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. Author manuscript; available in PMC: 2011 Jun 15.
Published in final edited form as: J Immunol. 2010 May 14;184(12):6695–6708. doi: 10.4049/jimmunol.0903130

FIGURE 4.

FIGURE 4

Treatment with Ag-pulsed anti-CTLA-4-Ab DCs suppresses insulitis in pre-diabetic mice. Eight week old euglycemic female NOD mice were left untreated or treated with β cell Ag pulsed control or anti-CTLA-4 Ab coated DCs as described for Fig. 3 and examined for insulitis 2 and 6 weeks after second injection with DCs. H&E-stained pancreatic sections were examined in a blinded fashion and the severity of lymphocyte infiltration was scored as described in materials and methods. Representative sections with different grades of insulitis are shown in the upper panel. Bar diagrams in the lower panel show the percentage of islets in each group with different grades of insulitis. One hundred islets from at least five mice were examined for each group.