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. Author manuscript; available in PMC: 2010 Dec 3.
Published in final edited form as: Nature. 2010 Jun 3;465(7298):641–644. doi: 10.1038/nature08974

Fig. 4. Cleavage-dependent control of C-gate dynamics.

Fig. 4

a. Superposition of noncovalent (grey)13 and cleavage (orange) complexes between topo II and DNA reveal how C-gate opening and closure is linked to active site status. The connection from the active-site tyrosines to the coiled-coil arms is coloured green/magenta. For clarity, the TOPRIM domains are hidden.

b. Close-up of positional shifts. (Upper) Upward movement of the active-site tyrosine upon becoming attached to the DNA. (Lower) Concomitant inward movement of the coiled-coil joint through a conserved salt bridge network.