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. Author manuscript; available in PMC: 2011 Jun 15.
Published in final edited form as: Biol Psychiatry. 2010 Apr 8;67(12):1128–1136. doi: 10.1016/j.biopsych.2010.02.008

Figure 4. Effects of single-cell block of K+ channels on excitability after chronic stress.

Figure 4

A) Cs+ (200 mM; blocker of a variety of K+ channels) did not closely mimic the effects of chronic stress on excitability (mixed design repeated measures ANOVA of each stimulation intensity, main effect of stress F(1,108) = 10.79, p=0.0014; main effect of stimulation intensity F(5,108) = 58.98, p<0.001; interaction F(5,108) = 1.52, p=0.19). B) Ba2+ (100 mM), another K+ channel blocker that also blocks KCa channels, negated the effects of chronic stress on excitability (mixed design repeated measures ANOVA of each stimulation intensity, main effect of stress F(1,126) = 1.36, p=0.247; main effect of stimulation intensity F(5,126) = 64.03, p<0.001; interaction F(5,126) = 0.103, p=0.991). * indicates p<0.05 between control and stress group in post-hoc unpaired t-tests with Bonferroni corrections.