Table 1.
Stimuli Initiating Cough: Mode of Action and Afferent Nerve Targets.
| Stimulus | Mode of Action | Afferent nerves targeted |
|---|---|---|
| Capsaicin | TRPV1 | C-fibers |
| Bradykinin | Bradykinin B2 receptors | C-fibers |
| Acid | TRPV1, Acid-Sensing Ion Channels | C-fibers, cough receptors |
| Particulates | Unknown | Cough receptors, C-fibers |
| TRPA1 agonists | TRPA1 | C-fibers |
| Prostaglandin E2 | Prostaglandin EP3 receptors | C-fibers |
| Nicotine | Nicotinic Receptors | C-fibers |
Abbreviations: TRPV1: transient receptor potential vanilloid 1; TRPA1: transient receptor potential ankyrin 1