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Summary of effects of the peptides on proteasome peptidase activities. Refer to Figures 3 and 4 for the % of activity changes and the I50 parameters (peptide concentrations required to achieve 50% inhibition of the maximal reaction rate of substrate digest by 20S proteasome).
| KKP | Tat1 | Tat2 | |
|---|---|---|---|
| ChT-L | No effect | Activation | Activation |
| ChT-L+SDS* | No effect | Inhibition | Inhibition |
| T-L | Inhibition | No effect | No effect |
| PGPH | Inhibition | Inhibition | Inhibition |
measured in the presence of 0.005% SDS
