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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Future Oncol. 2010 May;6(5):851–862. doi: 10.2217/fon.10.37

Table 1.

Genes that are methylated in gastric cancer and their function.

Gene name (abbreviation) Protein function Ref.
BCL2/adenovirus E1B-interacting protein 3 (BNIP3) Proapoptotic
Member of Bcl-2 family
[48]
Harakiri, BCL2-interacting protein (HRK) Proapoptotic [49]
Death-associated protein (DAP) Serine/threonine kinase
Proapoptotic
[50]
Solute carrier family 5 (iodide transporter), member 8 (SLC5A8) Sodium cotransporter
tumor suppressor
[51]
Inhibitor of DNA binding 4 (ID4) Transcriptional regulator [52]
Helicase-like transcription factor (HLTF) Tumor suppressor [53]
Retinoblastoma-interacting zinc-finger protein 1 (RIZ1) Zinc finger protein [54]
Runt-related transcription factor 3 (RUNX3) Tumor suppressor [55]
Deleted in liver cancer 1 (DLC1) Tumor suppressor [56]
Retinoic acid receptor β (RARB) Retinoid signaling [57]
TSPY-like 5 (TSPYL5) Cell growth [58]
Ras association (RalGDS/AF-6) domain family member 1 (RASSF1A) Putative tumor suppressor [59]
XIAP-associated factor 1 (XAF1) Putative tumor suppressor [60]
ADAM metallopeptidase domain 23 (ADAM23) Putative tumor suppressor [61]
Lysyl oxidase (LOX) Tumor suppressor [62]
Checkpoint with fork head-associated (FHA) and ring
finger (CHFR)
Mitotic checkpoint protein [63]