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. Author manuscript; available in PMC: 2011 Jun 2.
Published in final edited form as: J Am Chem Soc. 2010 Jun 2;132(21):7519–7527. doi: 10.1021/ja102339q

Figure 6.

Figure 6

Schematic representation of thiocillin SAR. Substitution of residues backed by red panels result in loss of antibiotic production, while those backed in yellow sustain production but lose activity. Substitutions at positions illustrated in green allow production of active antibiotic analogues.