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. Author manuscript; available in PMC: 2011 May 14.
Published in final edited form as: Cell. 2010 May 14;141(4):583–594. doi: 10.1016/j.cell.2010.04.020

Figure 5. In vivo exhaustion after knockdown of JARID1B.

Figure 5

(A) In vivo tumor growth is exhausted after 4 passages of serial xenotransplantation of JARID1B knockdown WM3734 cells in NOD/LtSscidIL2Rγnull mice (n=5 per sample) compared to the control (see also Figure S5). (B) Normalized growth ratio (tumor volumes of sh JARID1B tumors divided by volumes of sh scrambled tumors) over the cumulative growth phase of 27 weeks. (C) Significant decrease of pulmonary metastasis after subcutaneous injection of 5×105 JARID1B knocked down WM3899 cells into NOD/LtSscidIL2Rγnull mice (n=5 per sample). Shown is one representative from two independent experiments.