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. Author manuscript; available in PMC: 2010 Jul 6.
Published in final edited form as: Cancer Biol Ther. 2009 Jul 6;8(13):1212–1213. doi: 10.4161/cbt.8.13.8630

Figure 2. 4-NQO carcinogen treatment of K14/FLAG-hLRAT TG positive and negative mouse tongues.

Figure 2

Figure 2

K14/FLAG-hLRAT TG positive and negative mice were treated with 4-NQO (100 μg/ml) in the drinking water (see “Materials and Methods”) for 10 weeks and then maintained for another 15 weeks. A, a brief diagram of the experimental protocol. B, representative gross morphological observations of the mouse tongues and the gross tongue lesions grading system (10 ×). C, the grading of tongue lesions in K14/FLAG-hLRAT TG positive and negative control (not treated with carcinogen) mice. D, the grading of tongue lesions in K14/FLAG-hLRAT TG positive and negative mice treated with 4-NQO. The data (percentages in different grades) were analyzed by using a Fisher's exact probability test. Differences with a p value of < 0.05 (marked with an asterisk) between TG+ and TG- mouse tongue lesion grades were considered to be statistically significant.