Fig. 3.

Effect of apoCI-derived peptides on the serum residence and liver association of ¹²⁵I-LPS in vivo. ¹²⁵I-LPS (10 µg/kg) was incubated (30 min at 37°C) without or with a 20-fold molar excess of apoCI-derived peptides of the N-terminal helix (A) or of the C-terminal helix (B). The mixtures were injected via the vena cava inferior into anesthetized C57Bl/6 mice, and the serum residence (left panels) and liver association (right panels) of ¹²⁵I-LPS were determined at 30 min after injection. As a positive control, ¹²⁵I-LPS was incubated with apoCI_1–57 in a 1:1 molar ratio. Data are expressed as percentage of injected dose ± SD (n = 2–3).