Fig. 4.

Dose-dependent effects of peptides containing the full N-terminal helix (apoCI_1–30) and full C-terminal helix (apoCI_35–57) on the serum residence and liver association of ¹²⁵I-LPS. ¹²⁵I-LPS (10 µg/kg) was incubated (30 min at 37°C) without or with apoCI_1–30 (A) or apoCI_35–57 (B) at the indicated molar ratios. The mixtures were injected via the vena cava inferior into anesthetized C57Bl/6 mice, and the serum residence (left panels) and liver association (right panels) of ¹²⁵I-LPS were determined at 30 min after injection. As a positive control, ¹²⁵I-LPS was incubated with apoCI_1–57 in a 1:1 molar ratio. Data are expressed as percentage of injected dose ± SD (n = 2–3).