TABLE 1.
Comparison of the amino acid sequence of apoCI with those of proposed LPS-binding regions of several LPS-binding proteins
| LPS-binding proteins (amino acids) | Amino Acid Sequencea | Reference |
|---|---|---|
| BPI (85–100) | N I K I S G K W K A Q K R F L K M | Little et al. (37) |
| LBP (84–99) | S I R V Q G R W K V R K S F F K L | Taylor et al. (25) |
| Lf (28–34) | R K V R G P P | Elass-Rochard et al. (26) |
| ApoE (133–149)b | L R V R L A S H L R K L R K R L L | Lynch et al. (27) |
| MD2 (119–-132) | F S F K G I K F S K G K Y K | Mancek et al. (3) |
| CAP-18 (106–137) | G L R K R L R K F R N K IK E K LK K I G Q K I Q G L L P K L A | Larrick et al. (24) |
| LALF (32–50) | H Y R I K P T F R R L K WK Y K GK F | Hoes et al. (23) |
| ApoCI (1–30) | T P D V S S A L D K L K E F G N T L E D K A R E L I S R I K | |
| ApoCI (31–57) | Q S E L S A K M R E W F S E T F Q K V K E KL K I D S |
Modified from De Haas et al. (34).
a
Boldface residues represent basic amino acids; italic residues represent hydrophobic amino acids; underlined amino acids represent a comparable amino acid region.
b
The receptor-binding domain of apoE has not yet been described as a LPS-binding domain.