Fig. 2.

Schematic of the 2 × 2 experimental design. p53^+/+ apoE^−/− mice (n = 29) and p53^−/− apoE^−/− mice (n = 23) were placed on Western diet (42% calories from fat) at 6–8 weeks of age. They were divided into chloroquine (loading injection of 7 mg/kg, then biweekly injections of 3.5 mg/kg) versus saline injections. Interventions were performed at 1- and 2-month intervals as indicated. GTT, glucose tolerance test; ITT, insulin tolerance test.