TABLE 2.
Adjusted mean (± SE) LDL-C levels for SNPs that showed significant associations with LDL-C after adjusting for multiple comparisons
| Adjusted Means ± SE |
Variation in LDL-C Explained by SNP | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Gene Name | SNP rs no. | Chromosome | Position (bp)* | Study | 1/1 | 1/2 | 2/2 | Additive P-value | |
| LDLR | rs5929 | 19 | 11087800 | Family | 134 ± 2.3 | 124 ± 4.3 | 99 ± 14.7 | 4.6% | 0.00033 |
| Replication | 134 ± 1.1 | 127 ± 2.2 | 128 ± 7.6 | 0.5% | 0.004 | ||||
| LDLR | rs6511720 | 19 | 11063306 | Family | 136 ± 2.2 | 117 ± 4.3 | 93 ± 13.3 | 4.8% | 0.0014 |
| Replication | 135 ± 1.1 | 127 ± 2.0 | 124 ± 6.6 | 0.77% | 0.0002 | ||||
| PCSK9 | rs7517090 | 1 | 55287544 | Family | 138 ± 2.4 | 120 ± 3.4 | 98 ± 10.6 | 5.2% | 0.0005 |
| Replication | 134 ± 1.2 | 132 ± 1.7 | 121 ± 5.0 | 0.9% | 0.05 | ||||
| PLIN | rs8030806 | 15 | 88005145 | Family | 128 ± 2.4 | 137 ± 3.8 | 168 ± 12.8 | 1.5% | 0.0007 |
| Replication | 133 ± 1.1 | 133 ± 2.0 | 118 ± 7.5 | 1.1% | 0.44 | ||||
| 19q13.2 | rs389261 | 19 | 50112183 | Family | 124 ± 2.8 | 137 ± 3.1 | 140 ± 6.7 | 3.2% | 0.0013 |
| Replication | ND | ND | ND | ND | ND | ||||
1, major allele; 2, minor allele. Bold indicates significant P-value. ND, Not determined due to assay failure.
* Chromosomal position was based on the National Center for Biotechnology Information dbSNP, build 36.2.