TABLE 3.

Adjusted mean (± SE) TRIG levels for SNPs that showed significant associations with TRIG after adjusting for multiple comparisons

					Adjusted Means ± SE			Variation in TRIG Explained by SNP
Gene Name	SNP rs no.	Chromosome	Position (bp)*	Study Population	1/1	1/2	2/2		Additive P-value
HNF4A	rs3746575a	20	42491510	Family	82 ± 4.3	93 ± 3.3	114 ± 6.6	6.7%	0.0006
				Population-based	111 ± 2.6	112 ± 2.0	109 ± 2.9	0.21	0.57
HNF4A	rs11574739	20	42476364	Family	88 ± 3.1	94 ± 4.3	146 ± 11.7	5.7%	0.0012
				Population-based	112 ± 1.7	110 ± 2.5	110 ± 6.9	0.16	0.47
HNF4A	rs1028583	20	42484175	Family	85 ± 4.3	91 ± 3.4	112 ± 6.4	4.5%	0.0015
				Population-based	111 ± 2.6	111 ± 1.9	110 ± 2.9	0.011	0.96
HNF4A	rs3212198	20	42477776	Family	84 ± 3.9	93 ± 3.6	112 ± 6.5	5.1%	0.0019
				Population-based	112 ± 2.3	110 ± 2.0	112 ± 3.2	0.03%	0.78
HNF4A	rs6073435	20	42487002	Family	87 ± 3.7	92 ± 3.6	119 ± 7.6	4.3%	0.0025
				Population-based	113 ± 2.2	109 ± 2.0	114 ± 3.4	0.11%	0.87
LDLR	rs2569540	19	11099239	Family	106 ± 4.7	90 ± 3.6	83 ± 5.1	3.6%	0.001
				Population-based	114 ± 2.5	114 ± 20.0	111 ± 3.19	0.38	0.20
LDLR	rs5927	19	11094941	Family	86 ± 3.7	95 ± 3.9	108 ± 7.2	3.5%	0.0023
				Population-based	111 ± 2.0	112 ± 2.1	108 ± 4.3	0.28%	0.76
AdipoR2	rs11608456	12	1701455	Family	97 ± 2.9	79 ± 5.3	70 ± 18.3	3.8%	0.0007
				Population-based	ND	ND	ND	ND	ND
LPIN1	rs11890442	2	11828454	Family	85 ± 3.2	98 ± 4.3	119 ± 7.6	6.1%	0.0009
				Population-based	111 ± 2.0	110 ± 2.1	118 ± 4.1	0.61	0.31

1, Major allele; 2, minor allele.

^aIn the population-based Afro-Caribbean replication study rs6031593 was genotyped as a proxy SNP for rs3746575 genotyped in the family study. Bold indicates significant P-value. ND, Not determined due to assay failure.

* Chromosomal position was based on the National Center for Biotechnology Information dbSNP, build 36.2.