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. 2010 Jul;51(7):1929–1942. doi: 10.1194/jlr.M005744

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Copyright © 2010 by the American Society for Biochemistry and Molecular Biology, Inc.

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Fig. 5. — Deletion of MC4R decreases intestinal MTP activity and mRNA levels. Plasma samples from wild-type (Mc4r^+/+) and MC4R knockout (Mc4r^−/−) mice were subjected to gel filtration and fractions were analyzed for cholesterol (Panel A) and triglycerides (Panel B). Intestinal and liver samples from these animals (n = 6 per group) were used for MTP activity assays (Panels C and E). RNA was used to measure in triplicate MTP (Panels D and F) and ARPp0 mRNA. The ratio between MTP and ARPp0 in Mc4r^+/+ mice was used to normalize mRNA levels. Values are mean ± SD. *P < 0.05, ***P < 0.001 compared with wild-type mice. MC4R, melanocortin 4 receptor; MTP, microsomal triglyceride transfer protein.