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(a) Multiple sequence alignment of VP35 IID residues 301–340 from Ebola virus strains Zaire (ZEBOV), Reston (REBOV) and Sudan (SEBOV) and Marburg virus. The highly conserved basic residues Arg312, Lys319, Arg322 and Lys339 which are important for dsRNA binding are indicated by asterisks. (b) Residues Arg312, Lys319, Arg322 and Lys339 are located in the β-sheet subdomain of VP35 IID.
