Prediction of intrinsically disordered residues in human CREB protein CREB1 (SwissProt ID: P16220) by ANN-P (PONDR-FIT) and its 6 individual component predictors. Dark blue horizontal line is a MoRF region predicted by MoRF-II predictor. There are no intrinsically ordered domains or regions in this protein. However, one segment of this protein, KID domain, forms a crystallizable complex with the KIX domain of CREB binding protein (1KDX, [69]). This segment is indicated as M1e and is shown as light blue line. Red bar corresponds to the DNA-binding domain, whereas yellow bar indicated the dimerization domain. Plot (a) Represents predictions by PONDR-FIT, PONDR®VLXT, PONDR®VSL2, PONDR®VL3; Plot (b) represents data for PONDR-FIT, FoldIndex, IUPred, and TopIDP; Plot (c) compares PONDR-FIT with Avg5 and Avg6.