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. 2010 Jun 7;207(6):1247–1260. doi: 10.1084/jem.20092140

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© 2010 Jongbloed et al.

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Figure 6. — Poly I:C–activated CD141⁺ DCs induce superior CD4⁺ Th1 responses compared with CD1c⁺ DCs in an allogeneic MLR. (A) Allogeneic CD4⁺ T cell proliferation induced by unstimulated (−) or poly I:C activated (+) CD141⁺ DC and autologous CD1c⁺ DC, or in the absence of DC (no DC), measured by ³[H]-thymidine incorporation and expressed as counts per minute (cpm) after 6 d. (B) Cytokine production in the MLR cultures after 6 d. One representative donor of six is shown. (C and D) Secretion of IFN-γ (C) and IL-2 (D) in the allogeneic MLR cultures after 6 d. Each symbol represents DC isolated from the same donor in all graphs. *, P = 0.063; **, P = 0.031.