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. 2010 Jun 7;207(6):1247–1260. doi: 10.1084/jem.20092140

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© 2010 Jongbloed et al.

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Figure 9. — CD141⁺ DCs cross-present Ag from HCMV-infected necrotic fibroblasts. (A) Uptake of PKH-26–labeled HCMV-infected necrotic fibroblasts (nHCMV-Fb) by DC subsets after 12 h at 4 and 37°C by flow cytometry from a representative donor (left) and by three donors (right). (B) Uptake of nHCMV-Fb by confocal microscopy at 200×. Bars, 10 µm. (C) Cross-presentation of the pp65_95-503 epitope after uptake of nHCMV-Fb or control uninfected Fb by CD141⁺ DC and CD1c⁺ DC subsets to a pp65-specific CD8⁺ T cell line, as assessed by IFN-γ secretion by the T cells. Left, one representative of four donors. Right, four donors, expressed as specific IFN-γ production (nHCMV-Fb-uninfected Fb for each cell type).