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. Author manuscript; available in PMC: 2010 Jun 9.
Published in final edited form as: Cancer Res. 2007 Aug 1;67(15):7319–7326. doi: 10.1158/0008-5472.CAN-06-4625

Figure 1.

Figure 1

Morphologic transformation of NIH3T3 cells expressing double-mutant EGFR. A, immunoblot of NIH3T3 cells infected with retroviruses encoding the indicated EGFR constructs demonstrating comparable expression of all EGFR constructs (H-RasV12 and actin controls). B, cells expressing EGFR T790M/L858R and EGFR T790M/Del double mutants have striking morphologic differences from parental cells and those expressing EGFR wild-type (wt) or single mutants, as determined by phase-contrast microscopy. Cells expressing H-RasV12 also differ morphologically.