TABLE 1.
Summary of the E2F Mutant Phenotypes
| Alleles | Genotype | Mouse Phenotype | Reference(s) | |||||
|---|---|---|---|---|---|---|---|---|
| E2F1 | E2F2 | E2F3a | E2F3b | E2F4 | E2F5 | |||
| X | E2F1−/− | Decrease of apoptosis in immature thymocytes, tumors of older adults tissues especially reproductive organs. Decreased progenitor proliferation in the CNS. Decreased apoptosis and adult neurogenesis in the olfactory bulb and dentate gyrus. |
Cooper-Kuhn et. a1. 2002; Field et al. 1996; Wang et. al. 2007; Yamaski et al. 1996 |
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| X | E2F2−/− | Autoimmunity due to enhanced T lymphocyte proliferation | Murga et al. 2001 | |||||
| X | X | E2F3−/− | Mixed strain dependent viability, congenitive heart failure causes premature death in a pure 129/Sv strain. Decreased proliferation of adult neural precursors. |
Humbert et al. 2000b; Cloud et al. 2002; Wu et al. 2001; McClellan et al. 2007 |
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| X | E2F3a−/− | Viable, appear normal, aged mice have less white adipose tissue | Danielian et al. 2008; Chong et al. 2009; | |||||
| X | E2F3b−/− | Viable, appear normal | Danielian et al. 2008; Chong et al. 2009; | |||||
| X | E2F4−/− | Decreased erythroid proliferation, fetal anemia, growth retardation, and craniofacial defects. Reduced size of the ventral telencephalon, reduced number of neural precursors, and reduced expression of sonic hedqehog. |
Humbert et al. 2000a; Kinross et al. 2006; Rempel et, al, 2000; Ruzhynsky et al. 2007 |
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| X | E2F5−/− | Increased in cerebrospinal fluid causing hydrocephalus. | Lindeman et al. 1998 | |||||
| 1 | 1 | 1 | E2F1+/−E2F3+/− | Viable, Conqestive heart failure causes premature death. | Cloud et al. 2002 | |||
| 1 | X | X | E2F1+/−E2F3−/− | Viable, Congestive heart failure causes premature death. | Cloud et al. 2002 | |||
| X | 1 | 1 | E2F1−/−E2F3+/− | Viable, death from tumors - found to arise in E2F1−/−. | Cloud et al. 2002 | |||
| X | X | E2F1−/−E2F2−/− | Viable | Wu et al. 2001 | ||||
| X | X | X | E2F1−/−E2F2−/−E2F3b−/− | Viable | Tsai et al. 2008 | |||
| X | X | X | E2F1−/−E2F2−/−E2F3a−/− | Embryonic Lethal | Tsai etal. 2008 | |||
| X | X | E2F1−/−E2F3a−/− | Reduced viability, premature death, increase in brain mass. | Danielian et al. 2008; Tsai et al. 2008 | ||||
| X | X | X | E2F1−/−, E2F3−/− | Embryonic lethal | Wu et al. 2001 | |||
| X | X | E2F1−/−E2F3b−/− | Viable, no significant differences in tissue development. | Tsai et al. 2008 | ||||
| X | X | X | E2F2−/−,E2F3−/− | Embryonic lethal | Wu et al. 2001 | |||
| 1 | 1 | E2F4+/−E2F5+/− | Viable | Guabatz et al. 2000 | ||||
| 1 | X | E2F4E+/−F5−/− | Viable | Guabatz et al. 2000 | ||||
| X | 1 | E2F4−/−E2F5+/− | Reduced Viablility | Guabatz et al. 2000 | ||||
| X | X | E2F4−/−E2F5−/− | Late embryonic lethal | Guabatz et al. 2000 | ||||
The left side of the chart graphically displays the E2F alleles which are present (+/+, green; +/−, yellow; −/−, red).