. Author manuscript; available in PMC: 2011 Mar 1.

Published in final edited form as: Glia. 2010 Mar;58(4):377–390. doi: 10.1002/glia.20933

TABLE 3.

The Retinal Phenotype Caused by Deletion of Genes Encoding for Pocket Proteins is Dependent on Timing of Excision and Cell Type

Effects of pocket protein loss in the Retina
	Cre-recombinase Driver
Genotype	Gene promoter	Timing	Cells targeted	Pheontype in Retina	Reference(s)
Rb^lox/lox	Nestin (maternally transmitted)	E9.5	Neuronal progenitors (mosaic)	Increased apoptosis leading to a thin photoreceptor layer, Ectopic proliferation outside of inner granular layer	MacPherson et al. 2003, 2004
Rb^lox/lox	Pax6 alpha enhancer	E10.5	Peripheral retinal Progenitors	Reduced ganglion, bipolar, and rod cells due to apoptosis. Disorganization of INL. Defect in amacrine cell differentiation.	Chen et al. 2004, 2007; MacPherson et al. 2004
Rb^lox/−	Chx10	E11.5	Retinal progenitiors (mosaic)	Fewer rod cells but normal number of cone cells	Zhang et. al. 2004
Rb^lox/lox	IRBP	E13.5	Roads and Cones	No retinal phenotype	Vooijs et al. 2002
Rb^1/− p107^−/− chimeric	–	–	–	Retinodysplasia in neonates	Robanus-Maandag, 1998
Rb^−/− p107^−/− chimeric	–	–	–	Retinoblastoma by 14 weeks	Robanus-Maandag, 1998
Rb^lox/loxp107^−/−	Nestin (paternally transmitted)	E9.5	All cell types in the optic nerve	Retinodysplasia at E18.5, Mice die prior to weaning age	MacPherson et al. 2004
Rb^lox/loxp107^−/−	Pax6 alpha enhacer	E10.5	Peripheral retinal progenitors	Decreased ganglion bipolar, rod and cone cells. Ectopic division of precursor cells, but normal progenitor proliferation. Retinoblastoma develops.	Chen et al. 2004
Rb^lox/loxp107^−/−	IRBP	E13.5	Rods and Cones	No retinal phenotype	Vooijs et al. 2002
Rb^lox/loxp130^−/−	Nestin (paternally transmitted)	E9.5	All cell types in the optic nerve	Retinoblastoma develops at ~11 weeks	MacPherson et al., 2004
Rb^lox/loxp107^+/−p130^−/−	Chx10	E11.5	Retinal progenitors (mosaic)	Retinoblastoma develops at ~11 weeks	Ajioka et al. 2007
Rb^lox/loxE2F1^−/−	Pax6 alpha enhancer	E10.5	Peripheral retinal progenitors	Rescue of ectopic cellular division and death seen in Rb^lox/lox	Chen et.al. 2007
Rb^lox/loxE2F3a^−/−	Pax6 alpha enhancer	E10.5	Peripheral retinal progenitors	Rescue of amacrine cell differentiation defect seen in Rb^lox/lox	Chen et.al. 2007