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. 2010 Apr 30;65(7):1441–1447. doi: 10.1093/jac/dkq127

Table 2.

Mutations associated with fluoroquinolone resistance in FQR isolates tested in time–kill assays

MIC (mg/L)
 QRDR mutation(s)a
Organism Strain (phenotype) BES MXF CIP GyrA GyrB ParC ParE
S. aureus 1970149 (MSSA) 1 8 256 S84L none S80Y, E84G none
1711529 (MRSA) 1 8 256 S84L none S80Y, E84G none
S. epidermidis 1711557 (MSSE) 0.5 2 32 S84F none S80Y none
1711555 (MRSE) 0.5 2 32 S84Y none S80F none
S. pneumoniae 1115445 0.5 4 64 S81Y none S79Y, K137N none
H. influenzae 1408337 2 16 32 S84F, D88Y none S84R D420N, S458A, S474N

BES, besifloxacin; MXF, moxifloxacin; CIP, ciprofloxacin.

aCompared with reference strains (GenBank accession number): Newman (NC_009641), N315 (NC_002745) and NCTC 8325 (NC_007795); ATCC 12228 (NC_004461) and RP62A (NC_002976); TIGR4 (NC_003028), R6 (NC_003098) and G54 (NC_011072); and 86-028NP (NC_007146) and RdKW20 (NC_00090).