Table 3.
Subjects’ anthropometric, laboratory, and selected echocardiography characteristics. Values are mean ± SD
| Variable | Normal | Abnormal | P-value |
|---|---|---|---|
| Men/women | 20/9 | 3/1 | >0.2 |
| Age (yrs) | 60.9 ± 7.3 | 65.3 ± 7.3 | >0.2 |
| Height (cm) | 170.4 ± 9.1 | 174.3 ± 9.1 | >0.2 |
| Body mass (kg) | 89.3 ± 16.8 | 98.5 ± 16.8 | >0.2 |
| BMI (kg/m2) | 30.8 ± 5.6 | 32.7 ± 5.6 | >0.2 |
| BSA (m2) | 2.0 ± 0.2 | 2.1 ± 0.2 | >0.2 |
| Diabetes duration (years) | 9.1 ± 5.3 | 15.0 ± 5.3 | 0.08 |
| HbA1c (%) | 8.1 ± 1.3 | 9.0 ± 1.3 | >0.2 |
| Systolic blood pressure (mm Hg) | 141.1 ± 15.3 | 161.0 ± 15.4 | 0.02 |
| Diastolic blood pressure (mm Hg) | 82.0 ± 7.8 | 86.5 ± 7.8 | >0.2 |
| eGFR (ml/min) | 118 ± 40 | 116 ± 38 | >0.20 |
| BNP (pmol/l) | 5.3 ± 3.4 | 26.0 ± 3.4 | <0.001 |
| ln BNP | 1.4 ± 0.8 | 3.1 ± 0.8 | <0.001 |
| NT-proBNP (ng/l) | 48.3 ± 47.4 | 360.0 ± 47.4 | <0.001 |
| ln NT-proBNP | 3.4 ± 1.1 | 5.8 ± 1.1 | <0.001 |
| LVMI (g/m2) | 80.7 ± 16.6 | 93.2 ± 16.6 | 0.17 |
| LVDVI (ml/m2) | 49.4 ± 7.8 | 56.8 ± 7.8 | 0.07 |
| LVSVI (ml/m2) | 18.3 ± 4.3 | 21.1 ± 4.3 | >0.20 |
| LAVI (ml/m2) | 25.2 ± 4.1 | 38.9 ± 4.1 | <0.001 |
| IVSI (mm/m2) | 5.1 ± 0.4 | 5.2 ± 0.4 | >0.2 |
| POSTI (mm/m2) | 4.5 ± 0.4 | 4.5 ± 0.4 | >0.2 |
| EF (%) | 63.1 ± 5.2 | 63.0 ± 5.2 | > 0.2 |
| E/A | 0.9 ± 0.3 | 1.1 ± 0.3 | >0.2 |
| DT (msec) | 219 ± 44 | 211 ± 44 | >0.2 |
| S/D | 1.4 ± 0.3 | 1.2 ± 0.3 | >0.2 |
| E/Em | 10.0 ± 3.6 | 12.5 ± 3.6 | 0.20 |
| Sm septal (cm/s) | 7.6 ± 1.7 | 7.2 ± 1.7 | >0.2 |
| Em septal (cm/s) | 6.7 ± 1.4 | 7.0 ± 1.4 | >0.2 |
| Am septal (cm/s) | 9.7 ± 1.8 | 8.2 ± 1.8 | 0.09 |
| Sm lateral (cm/s) | 9.1 ± 1.5 | 7.5 ± 1.5 | 0.07 |
| Em lateral (cm/s) | 8.8 ± 2.7 | 8.3 ± 2.7 | >0.2 |
| Am lateral (cm/s) | 11.6 ± 2.4 | 9.8 ± 2.4 | 0.19 |
Notes: The study population is divided into those with normal versus abnormal diastolic function.
Abbreviations: BNP, brain natriuretic peptide; NT-proBNP, N-terminal pro brain natriuretic peptide. Indexed for BSA: POSTI, posterior wall thickness; IVSI, interventricularseptum thickness; LVMI, left ventricular mass; LVDVI, left ventricular end-diastolic volume; LVSVI, left ventricular end-systolic volume; LAVI, left atrial end-systolic volume; EF, ejection fraction; E, peak of early diastolic; A, late diastolic; mitral flow velocities. DT, deceleration time of E-wave; S, pulmonary vein peak velocities systole; D, diastole. pulsed tissue Doppler imaging velocities; Sm, peak systolic; Em, early diastolic velocities; Am, late diastolic velocities.