Representative photomicrographs show [3H]CP55,940 binding in brains derived from adult rats that were either (top: a, b) group or (bottom: c, d) isolation reared and concomitantly (right: b, d) handled or (left: a, c) not handled post-weaning. Sections were collected −2.30 mm from bregma. CA 1–3, molecular layers of hippocampus CA 1–3; DG, dentate gyrus; vlTN, ventrolateral thalamic nuclei. Scale bar equals 1mm.