Handled rats show altered cannabinoid receptor densities in the limbic loop of the basal ganglia. Handled rats exhibit increased cannabinoid receptor densities in the (a) lateral globus pallidus, (b) cingulate cortex, and (c) piriform cortex, but decreased cannabinoid receptor density in the (d) hippocampus, relative to non-handled rats. Data are mean ± S.E.M. ##P < 0.01, #P < 0.05 vs. Non-Handled (ANOVA). Representative photomicrographs are shown in Fig. 4–5. Cg, cingulate cortex; Hippo, hippocampus CA 1–3 and dentate gyrus; lGP, lateral globus pallidus; Pir, piriform cortex.