Table 1.
Brain Region | Group Reared Non-Handled | Group Reared Handled | Socially Isolated Non-Handled | Socially Isolated Handled |
---|---|---|---|---|
Basal Ganglia/Striatum | ||||
Caudal caudate putamen (CPu) | 13.71 ± 0.87++ | 22.68 ± 1.90 | 15.73 ± 1.44+ | 15.99 ± 1.66+ |
Caudal dorsal CPu | 12.83 ± 0.80+ | 19.64 ± 2.21 | 14.27 ± 0.77++ | 15.08 ± 0.97 |
Caudal ventral CPu | 13.06 ± 0.87 | 21.13 ± 2.24 | 16.10 ± 2.28 | 16.40 ± 3.18 |
Rostral CPu | 16.28 ± 0.91 | 12.63 ± 1.91 | 18.42 ± 2.63 | 17.48 ± 1.42 |
Rostral dorsolateral CPu | 19.35 ± 1.17 | 15.34 ± 2.36 | 21.20 ± 3.04 | 20.64 ± 1.75 |
Rostral dorsomedial CPu | 14.10 ± 0.69 | 10.60 ± 1.50 | 16.01 ± 2.15* | 14.63 ± 0.99* |
Rostral ventrolateral CPu | 17.32 ± 0.93 | 13.93 ± 2.48 | 20.42 ± 3.26* | 20.67 ± 2.31* |
Rostral ventromedial CPu | 14.56 ± 0.71 | 11.12 ± 1.65 | 16.48 ± 2.62 | 15.64 ± 1.53 |
Lateral globus pallidus | 34.72 ± 4.24 | 48.72 ± 2.32 | 35.78 ± 4.25* | 39.95 ± 2.20* |
Nucleus accumbens core | 12.16 ± 0.72 | 9.13 ± 1.25 | 13.54 ± 2.49 | 13.11 ± 1.38 |
Nucleus accumbens shell | 11.39 ± 0.74 | 8.59 ± 1.39 | 12.21 ± 2.19 | 12.65 ± 1.41 |
Olfactory tubercle | 7.57 ± 0.41 | 5.20 ± 0.71 | 8.17 ± 1.67 | 8.48 ± 1.00 |
Cerebral Cortex | ||||
Cingulate cortex | 9.00 ± 0.58 | 13.09 ± 1.38## | 9.01 ± 0.47 | 10.74 ± 0.88## |
Motor cortex | 9.76 ± 0.85 | 7.55 ± 0.95 | 10.30 ± 1.58 | 10.13 ± 0.92 |
Piriform cortex | 6.95 ± 0.47 | 9.57 ± 1.16# | 7.51 ± 0.49 | 8.62 ± 1.08# |
Septum | ||||
Lateral septum | 12.47 ± 1.04 | 9.30 ± 1.56 | 10.27 ± 1.54 | 13.48 ± 1.68 |
Limbic diagonal band nuclei | 13.66 ± 0.95 | 10.56 ± 1.13 | 12.71 ± 1.23 | 11.63 ± 1.51 |
Vertical limbic diagonal band | 16.08 ± 0.89 | 12.67 ± 1.60 | 14.21 ± 1.52 | 12.57 ± 1.60 |
Amygdala | ||||
Basolateral amygdala nuclei | 9.08 ± 0.70 | 9.93 ± 1.02 | 9.28 ± 1.29 | 8.12 ± 0.88 |
Central amygdaloid nuclei | 12.04 ± 0.60 | 11.11 ± 1.19 | 10.29 ± 1.06 | 10.07 ± 1.10 |
Hypothalamus & Thalamus | ||||
Anterior thalamic nuclei | 4.19 ± 0.17++ | 5.66 ± .047 | 4.34 ± 0.22+ | 4.20 ± 0.23++ |
Arcuate nuclei | 5.92 ± 0.47 | 6.63 ± 1.15 | 6.01 ± 0.78 | 6.33 ± 1.67 |
Medial preoptic area | 6.99 ± 0.60 | 8.44 ± 0.92 | 7.15 ± 0.87 | 7.42 ± 0.56 |
Superoptic nucleus | 8.80 ± 0.66 | 11.25 ± 1.31 | 7.26 ± 1.02* | 7.86 ± 0.77* |
Ventrolateral thalamic nuclei | 7.16 ± 0.40 | 6.70 ± 0.58 | 6.14 ± 0.56* | 5.53 ± 0.47* |
Hippocampal Formation | ||||
CA1 – CA3 & dentate gyrus | 13.74 ± 0.70 | 10.85 ± 1.02# | 12.31 ± 0.74 | 11.95 ± 0.66# |
CA1 – CA3 | 14.82 ± 0.66 | 11.67 ± 1.02# | 14.07 ± 0.91 | 13.58 ± 0.96# |
CA1 | 17.39 ± 1.05 | 12.59 ± 1.54 | 16.80 ± 1.47 | 16.76 ± 1.33 |
CA2 | 17.91 ± 0.82 | 13.00 ± 1.85# | 15.95 ± 1.21 | 15.14 ± 0.62# |
CA3 | 18.50 ± 0.79 | 13.61 ± 2.18 | 16.37 ± 1.10 | 17.02 ± 1.45 |
Dentate gyrus | 16.50 ± 0.85 | 13.50 ± 1.32 | 13.73 ± 1.25 | 13.77 ± 0.91 |
Data are mean ± S.E.M. (n = 8 per group);
P < 0.05 vs. Group-Reared;
P < 0.01,
P < 0.05 vs. Non-Handled;
P < 0.01,
P < 0.05 vs. Group-Reared/Handled.