TABLE I.
Characterization of Williams Syndrome (WS) Cohort
| Adults with Williams syndrome (n = 28) | |
|---|---|
| Age (y)a | 34.9 (9.7) |
| Sex | |
| M | 10 |
| F | 18 |
| BMI (kg/m2)a | 26.19 (5.86) |
| Dist. of BMI | |
| <20 | 6 |
| ≥ 20–25 | 4 |
| ≥ 25–30 | 13 |
| >30 | 5 |
| Glucose tolerance statusb | |
| Normal glucose tolerance | 7 (25) |
| Impaired glucose tolerance | 11 (39) |
| Previously unrecognized diabetes | 10 (36) |
| 1st degree relative with diabetes mellitusb,c | |
| Yes | 3 (12) |
| No | 23 (88) |
| Medicationsb,d | |
| Any medications | 21 (75) |
| Beta-blockers | 7 (25) |
| Other anti-HTN | 5 (18) |
| Psychiatric medications | 14e (50) |
| % Total body fata (16 missing) | 29.67 (11.74) |
| Mean HbA1c (%)a | 5.38 (0.56) |
HTN, hypertension; HbA1c, hemoglobin A1C.
a
Mean (SD).
b
Frequency (%).
c
Two patients adopted.
d
Several patients were taking multiple medications.
e
The most common medications used to treat psychiatric symptoms were SSRIs; one male patient, taking olanzapine (Zyprexa), was classified as having IGT.