Fig. 3.

Effects of acute administration of losartan (10 mg/kg, iv) on mean arterial blood pressures (A) and the pressor responses to intravenous administration of 50 ng of ANG II (B) in transgene-negative Fischer 344 rats fed a normal diet containing 0.3% I3C (non-induced; filled bars); Cyp1a1-Ren2 rats induced with 0.3% I3C (0.3% I3C; hatched bars) for 11 days; Cyp1a1-Ren2 rats induced with 0.3% I3C and treated chronically with the ACE inhibitor, lisinopril (50 mg/L in drinking water) (0.3% I3C+Lis; cross-hatched bars). **P<0.01 vs. corresponding control value; † P<0.05 vs. non-induced.