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Effects of acute administration of losartan (10 mg/kg, iv) on glomerular filtration rate (A) and renal plasma flow (B) in transgene-negative Fischer 344 rats fed a normal diet containing 0.3% I3C (non-induced; filled bars); Cyp1a1-Ren2 rats induced with 0.3% I3C (0.3% I3C; hatched bars) for 11 days; Cyp1a1-Ren2 rats induced with 0.3% I3C and treated chronically with the ACE inhibitor, lisinopril (50 mg/L in drinking water) (0.3% I3C+Lis; cross-hatched bars).
