Table 2.
Estimated percent changes and 95% CIs in DNA adducts in lung and blood MNC per 1010 nucleotides by GSTs polymorphisms and NAT2 activity
| DNA adduct in lung |
DNA adduct in blood MNC |
|||||
|---|---|---|---|---|---|---|
| n (%) | Adjusted GM (95% CI)† | %change (95% CI) | n (%) | Adjusted GM(95% CI)† | %change (95% CI) | |
| GSTM1 | ||||||
| Null | 56 (43.8) | 173.9 (100.9 to 299.7) | 150.3 (35.4 to 362.6)** | 24 (46.1) | 88.2 (33.5 to 231.9) | 267.4 (28.2 to 952.9)** |
| Wild-type | 72 (56.2) | 69.5 (41.1 to 117.3) | Reference | 28 (53.9) | 24.0 (8.9 to 64.4) | Reference |
| GSTP1 | ||||||
| AG or GG | 57 (48.3) | 115.1 (65.9 to 201.0) | 9.7 (-40.7 to 103.0) | 27 (54.0) | 67.5 (22.5 to 202.7) | 115.4 (-30.1 to 564.1) |
| AA | 62 (51.7) | 104.9 (63.0 to 174.8) | Reference | 23 (46.0) | 31.3 (12.9 to 76.1) | Reference |
| GSTT1 | ||||||
| Null | 17 (14.0) | 119.7 (53.0 to 270.5) | 18.6 (-50.5 to 184.0) | 5 (9.4) | 57.2 (12.1 to 269.8) | 54.6 (-68.2 to 652.1) |
| Wild-type | 104 (86.0) | 100.9 (73.0 to 139.5) | Reference | 48 (90.6) | 37.0 (21.8 to 62.7) | Reference |
| NAT2 activity | ||||||
| Slow | 48 (58.5) | 144.9 (87.1 to 241.2) | 73.9 (-3.2 to 212.4)* | 23 (67.7) | 39.0 (16.6 to 91.8) | -28.2 (-70.5 to 74.8) |
| Rapid | 34 (41.5) | 83.3 (48.5 to 143.2) | Reference | 11 (32.3) | 54.3 (20.0 to 147.4) | Reference |
*
P < 0.1
**
P < 0.05
***P < 0.01
Note: Coefficients are expressed as percent changes in aromatic DNA adducts-associated GST polymorphisms and NAT2 activity adjusted for age at diagnosis, sex, smoking status, pack years, and GSTM1, GSTT1, GSTP1, and NAT2 gene.
†
Adjusted for age at diagnosis, sex, smoking status, pack years, and GSTM1, GSTT1, GSTP1, and NAT2 gene.