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. Author manuscript; available in PMC: 2011 May 1.
Published in final edited form as: Ann Hum Genet. 2010 Mar 31;74(3):195–201. doi: 10.1111/j.1469-1809.2010.00570.x

Table 3. RESULTS FROM LOGISTIC REGRESSION MODELS OF NOS2A – CIGARETTE SMOKING INTERACTION AND AMD.

(Association between cigarette smoking and age-related macular degeneration (AMD), stratified by genotypes at NOS2A single nucleotide polymorphisms rs2248814 and rs1060826 was determined adjusting for age and sex. Odds ratios (OR) and 95% confidence intervals (95% CI) are presented for the association of “ever” smoking with AMD in 263 grade 5 cases and 169 grade 1 controls. Statistically significant associations (p<0.05) between cigarette smoking and AMD are noted in bold.)

SNP OR 95% CI p-value Cases Controls
AA GENOTYPE
rs2248814 35.98 (3.19, 405.98) 0.0038 33 17
rs1060826 35.63 (3.12, 406.67) 0.004 33 17
AG GENOTYPE
rs2248814 3.05 (1.38, 6.74) 0.0058 136 70
rs1060826 2.83 (1.27, 6.31) 0.011 132 68
GG GENOTYPE
rs2248814 2.10 (0.91, 4.84) 0.082 95 60
rs1060826 2.13 (0.94, 4.85) 0.072 98 60