Fig. 8.

Purified phage bearing anti-Aβ antibody fragment efficiently clears amyloid deposits after intracranial delivery. Purified phage C1.27 bearing anti-Aβ antibody fragment, as well as negative control phage or monoclonal 6E10 antibody, were intracranially injected into the left hippocampus of 14-month-old Tg2576 mice. Seven days later, brain sections were immunostained for Aβ with polyclonal rabbit anti-Aβ antibody. Original magnification was at 40x. Aβ load from the contralateral side was considered as 100%. Data are presented as mean±SE.