. Author manuscript; available in PMC: 2010 Jun 10.

Published in final edited form as: Regul Toxicol Pharmacol. 2009 Jan 23;53(3):195–204. doi: 10.1016/j.yrtph.2009.01.003

Table 1.

Physiologic Parameters used in the PBPK model for Rat and Human

Variable	Symbol	Compartment	Rat	Human

Initial Body Weight (Kg)	WtO	Body Weight/Cardiac Output	0.298^A	60^C

Cardiac Output (L/min/Kg^0.75) Rat (L/min/Kg) Human	Qcar	Body Weight/Cardiac Output	0.273^C	0.086^C

Fraction of Oral Dose that reaches Blood through Lymphatic System	Fkl	Split	0.1^G	0.1^G

Fecal excretion constant (Fraction of Dose)	Kf	Absorption	0.1^E	0.1^E–^F

Tissue Volume Fraction of Bodyweight	Vc	Liver	0.037	0.0257
		Testes	0.013^A	0.00057^D
		Kidney	0.0073	0.0044
		Slowly Perfused	0.81	0.437
		Richly Perfused	0.0596	0.166
		Fat	0.17	0.214
		Blood	0.07	0.08
			All other values^C	All other values^C

Fraction of Tissue Volume that is Blood	Vbc	Liver	0.21	0.11
		Testes	0.03^A	0.03^D
		Kidney	0.16	0.36
		Slowly Perfused	0.04	0.04
		Richly Perfused	0.21	0.21
		Fat	0.05	0.02
			All other values^C	All other values^C

Blood Flow to Tissue (Fraction of Cardiac Output)	Qc	Liver	0.18	0.1854
		Testes	0.01	0.0004^D
		Kidney	0.16	0.175
		Slowly Perfused	0.16	0.16
		Richly Perfused	QTOT-QTOT(ΣQc)^F	QTOT-QTOT(ΣQc)^F
		Fat	0.07	0.052
			All other values^C	All other values^C

Fraction of Tissue Weight that is Protein	Pfl	Liver	0.348^A	0.348^{Rat Value}

Fraction of Tissue Weight that is Cytosolic Protein	Pfc	Liver	0.042^A	0.02^B

Weight of Tissue (grams)	W	Liver	12.5^C	1800^A

Source

Experiment

Experiment (Data from SRI)

Estimated