. Author manuscript; available in PMC: 2010 Jun 10.

Published in final edited form as: Regul Toxicol Pharmacol. 2009 Jan 23;53(3):195–204. doi: 10.1016/j.yrtph.2009.01.003

Table 2.

Metabolic Parameters used in the PBPK model for Rat and Human.

Variable	Symbol	Rat Liver	Rat Optimized	Human Liver
Hydroxylation Km (nM)	KmOH	587,000^A	587,000	124,000^A
Vmax Hydroxylation (nmol/min/g protein)	VmaxOH	8.33^A	8.33	58.6^A
Km Sulfoxidation (nM)	KmSO	2,837,000^A	360,000^C	981,000^A
Vmax Sulfoxidation (nmol/min/g protein)	VmaxSO	638^A	638	510^A
Km GST conjugation (nM)	KmGST1	305,500^B	304,100	91,250^B
Vmax GST Conjugation (nmol/min/g Cytosolic Protein)	VmaxGST1	4,208^B	5,383	323^B

Source

Optimized.