Table 4.
No | Dose Regimen | Dose (mg/kg) | Vehicle | Animal | N per time point | Blood Cmax (ng/ml) | Reference |
---|---|---|---|---|---|---|---|
1 | Single intravenous | 1.5 | Glycerol formal | Rat | 3–4 | 368 | |
2 | Single intravenous | 15 | Glycerol formal | Rat | 3–4 | 6,852 | |
3 | Single oral | 10 | Glycerol formal | Rat | 3–4 | 152 | |
4 | Single oral | 100 | Glycerol formal | Rat | 3–4 | 2,723 | |
5 | Single oral | 5.06 (mg) | Gelatin capsule | Human | 2 | 2.3 | Batten et al. (1992) |