Table 3.

SPM risk associated with FAS and FASLG polymorphisms after index SCCHN

No. risk genotypes	Total (No. =1,286)		SPM-free (No. =1,166)		SPM (No. =120)		Pa	HR(95% CI)b
	No.	%	No.	%	No.	%
0–1 (Ref.c)	235	18.3	221	19.0	14	11.7	0.103	1.00 (Ref)
2	480	37.3	438	37.6	42	35.0		1.43 (0.78–2.63)
3	420	32.7	375	32.1	45	37.5		1.83 (1.00–3.36)
4	151	11.7	132	11.3	19	15.8		2.53 (1.26–5.06)
Trend								P=0.004

^aχ² test for differences in the distribution of combined genotypes between the patients who developed SPM and the patients who did not.

^bAdjusted for age, sex, ethnicity, tobacco smoking and alcohol drinking in a Cox model.

^cRef. = reference group.